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Stem Cell and Regenerative
Biology Graduate Program
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Prof Info.
임정훈Chunghun Lim
생명과학기술대학 생명과학과 줄기세포 및 재생생물학 대학원
줄기세포 및 분화연구 발생 및 질환 모델 조직공학 및 오가노이드
유도만능줄기세포(iPSC)와 섬유아세포(fibroblast)의 신경분화 모델을 활용하여 단백질 합성 과정에서 일어나는 리보솜의 정체와 충돌, 그로 인한 단백질 번역 품질 관리와 번역 스트레스의 신호 전달이 어떻게 신경발달, 신경질환 및 노화를 제어하는지 관심을 가지고 연구하고 있습니다.
매우 근본적인 생명 현상 가운데 하나인 리보솜의 유전암호 해독 과정과 이로부터 유래되는 세포 스트레스의 새로운 원리를 이해함으로써 신경질환과 노화를 억제할 수 있는 혁신적인 기술을 개발하고 이를 통해 인류의 건강한 삶에 이바지하고자 합니다.
At the Molecular Neurobiology Laboratory, we employ neural differentiation models of patient-derived induced pluripotent stem cells (iPSCs) and fibroblasts to investigate how ribosome stalling and collisions during translation, as well as the subsequent co-translational quality control and translational stress signaling, regulate neurodevelopment, neurodegenerative diseases, and aging.
Understanding the fundamental principles of ribosome-mediated decoding and relevant stress responses will facilitate the development of innovative technologies for treating these conditions, thereby contributing to healthier human lives.
매우 근본적인 생명 현상 가운데 하나인 리보솜의 유전암호 해독 과정과 이로부터 유래되는 세포 스트레스의 새로운 원리를 이해함으로써 신경질환과 노화를 억제할 수 있는 혁신적인 기술을 개발하고 이를 통해 인류의 건강한 삶에 이바지하고자 합니다.
At the Molecular Neurobiology Laboratory, we employ neural differentiation models of patient-derived induced pluripotent stem cells (iPSCs) and fibroblasts to investigate how ribosome stalling and collisions during translation, as well as the subsequent co-translational quality control and translational stress signaling, regulate neurodevelopment, neurodegenerative diseases, and aging.
Understanding the fundamental principles of ribosome-mediated decoding and relevant stress responses will facilitate the development of innovative technologies for treating these conditions, thereby contributing to healthier human lives.
- 2023 - 현재 Associate Professor, Department of Biological Sciences, KAIST
- 2013 - 2023 Assistant/Associate/Full Professor, Department of Biological Sciences, UNIST
- 2007 - 2013 Postdoctoral Fellow, Department of Neurobiology, Northwestern University (Advisor: Dr. Ravi Allada)
- 2004 - 2007 Postdoctoral Fellow, Department of Biological Sciences, KAIST (Advisor: Dr. Joonho Choe)
- 2001 - 2004 Ph.D. Department of Biological Sciences, KAIST
- 1999 - 2001 M.S. Department of Biological Sciences, KAIST
- 1995 - 1999 B.S. Department of Biological Sciences, KAIST
- translation dynamics, proteostasis, neurological disorders, aging
- Lee, S.*, Park, D.*, Lim, C.**, Kim, J.-I.**, and Min, K.-T.** (2022). mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth. BMC Biology 20, 12. *co-first authors; **co-corresponding authors.
- Lee, J.*, Lim, C.*, Han, T.-H., Andreani, T., Moye, M., Curran, J., Johnson, E., Kath, W. L., Diekman, C.O., Lear, B.C., and Allada, R. (2021). The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms. Proc Natl Acad Sci USA 118, e2110767118. *co-first authors.
- Park, J.*, Lee, J.*, Kim, J.-H., Lee, J., Park, H., and Lim, C. (2021). ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. Nucleic Acids Research 49, 11294-11311. *co-first authors.
- Lee, J., Park, J., Kim, J.-H., Lee, G., Park, T.-E., Yoon, K.-J., Kim, Y.K., and Lim, C. (2020). LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient. PLOS Biology 18, e3001002.
- Kanaya, H.J., Park, S.*, Kim, J.-H.*, Kusumi, J., Krenenou, S., Sawatari, E., Sato, A., Lee, J., Bang, H., Kobayakawa, Y., Lim, C.**, and Itoh, T.Q.** (2020). A sleep-like state in Hydra unravels conserved sleep mechanisms during the evolutionary development of the central nervous system. Science Advances 6, eabb9415. *co-second authors; **co-corresponding authors.
- Ki, Y. and Lim, C. (2019). Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. eLife 8, e40593.
- Sonn, J.Y.*, Lee, J.*, Sung, M.K., Ri, H., Choi, J.K., Lim, C.**, and Choe, J.** (2018). Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Proc Natl Acad Sci USA 115, 7129-7134. *co-first authors; **co-corresponding authors.
- Lee, J.*, Yoo, E.*, Lee, H.*, Park, K., Hur, J.-H., and Lim, C. (2017). LSM12 and ME31B/DDX6 define distinct modes of post-transcriptional regulation by the ATAXIN-2 protein complex in Drosophila circadian pacemaker neurons. Molecular Cell 66, 129-140. *co-first authors
- Lim, C.** and Allada, R.** (2013). Emerging roles for post-transcriptional regulation in circadian clocks. Nature Neuroscience 16, 1544-1550. **co-corresponding authors.
- Lim, C. and Allada, R. (2013). ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila. Science 340, 875-879.
- Lim, C.*, Lee, J.*, Choi, C., Kilman, V.L., Kim, J., Park, S.M., Jang, S.K., Allada, R.**, and Choe, J.** (2011). The novel gene twenty-four defines a critical translational step in the Drosophila clock. Nature 470, 399-403. *co-first authors; **co-corresponding authors.
- Lim, C.*, Chung, B.Y.*, Pitman, J.L., McGill, J.J., Pradhan, S., Lee, J., Keegan, K.P., Choe, J.**, and Allada, R.** (2007). Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila. Curr Biol 17, 1082-1089. *co-first authors; **co-corresponding authors.