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Stem Cell and Regenerative
Biology Graduate Program
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이승재Seung-Jae V. Lee
생명과학기술대학
발생 및 질환 모델
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RNA 매개 건강장수 연구센터에서는 생명체의 노화 과정에서 변화하는 RNA가 어떻게 노화 및 장수에 영향을 미치는지를 연구하고 있습니다.
구체적으로 mRNA의 품질 조절 활성, circular RNA, long noncoding RNA, tRNA-derived small RNA 등 noncoding RNA의 양적 변화가 노화에 어떤 역할을 수행하는지를 연구합니다.
연구의 시스템으로는 노화 연구에 최적의 모델인 예쁜꼬마선충을 기본으로 포유동물세포주 및 마우스에서 진화적 보존성을 테스트합니다.
The Center for RNA-Mediated Healthy Longevity studies how changes in RNA during the aging process affect aging and longevity.
Specifically, we investigate the roles of mRNA quality control, and noncoding RNAs including circular RNA, long noncoding RNA and tRNA-derived small RNA, in aging.
Our research team primarily utilizes Caenorhabditis elegans, an optimal model for aging research, and also tests whether our findings are evolutionarily conserved in cultured mammalian cells and mice.
구체적으로 mRNA의 품질 조절 활성, circular RNA, long noncoding RNA, tRNA-derived small RNA 등 noncoding RNA의 양적 변화가 노화에 어떤 역할을 수행하는지를 연구합니다.
연구의 시스템으로는 노화 연구에 최적의 모델인 예쁜꼬마선충을 기본으로 포유동물세포주 및 마우스에서 진화적 보존성을 테스트합니다.
The Center for RNA-Mediated Healthy Longevity studies how changes in RNA during the aging process affect aging and longevity.
Specifically, we investigate the roles of mRNA quality control, and noncoding RNAs including circular RNA, long noncoding RNA and tRNA-derived small RNA, in aging.
Our research team primarily utilizes Caenorhabditis elegans, an optimal model for aging research, and also tests whether our findings are evolutionarily conserved in cultured mammalian cells and mice.
- 2019.2 - 현재 Professor, KAIST, South Korea
- 2016.3 - 2019.2 Tenured Associate Professor, POSTECH, South Korea
- 2013.3 - 2016.2 Associate Professor, POSTECH, South Korea
- 2009.1 - 2013.2 Assistant Professor, POSTECH, South Korea
- 2004.4 - 2008.12 Postdoctoral Fellow, University of California, San Francisco, CA, USA
- 2003.4 - 2004.3 Postdoctoral Fellow, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Ph. D. 2003 Department of Biological chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- M. S. 1997 Department of Microbiology, Seoul National University, Seoul, South Korea
- B. S. 1995 Department of Microbiology, Seoul National University, Seoul, South Korea
- Regulation of aging and longevity
- Molecular genetics using Caenorhabditis elegans
- The role of mRNA surveillance and ribosome-associated quality control in aging
- Functional analysis of noncoding RNAs in aging processes
- Sohn, J.#, Kwon, S.#, Lee, G.Y.#, Kim, S.S., Lee, Y., Lee, J., Jung, Y., Ham, S., Park, H.E.H., Park, S., Ha, S.G., Lee, D., and Lee, S.J.V.* (2024) HLH-30/TFEB-regulated autophagy mediates sexual dimorphism in immunity in Caenorhabditis elegans. Autophagy doi: 10.1080/15548627.2024.2375779
- Kim, E.#, Annibal, A.#, Lee, Y.#, Park, H.E.H.#, Ham, S.#, Jeong, D.E., Kim, Y., Park, S., Kwon, S., Jung, Y., Park, J., Kim, S.S., Antebi, A.*, and Lee, S.J.V.* (2023) Inhibition of mitochondrial aconitase enhances immunity by modulating oxaloacetate and the mitochondrial UPR. Nature Comm. doi: 10.1038/s41467-023-39393-6
- Ham, S.#, Kim, S.S.#, Park, S., Kim, E.J.E., Kwon, S., Park, H.E.H., Jung, Y., and Lee, S.J.V.* (2022) Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans. Genome Res. 32(11-12):2003-2014
- Jung, Y.#, Artan, M.#, Kim, N.#, Yeom, J.#, Hwang, A.B., Jeong, D.E., Altintas, O., Seo, K., Seo, M., Lee, D., Hwang, W., Lee, Y., Sohn, J., Kim, E.J.E., Ju, S., Han, S.K., Nam, H.J., Adams, L., Ryu, Y., Moon, D.J., Kang, C., Yoo, J.Y., Park, S.K., Ha, C.M., Hansen, M., Kim, S., Lee, C.*, Park, S.Y.*, and Lee, S.J.V.* (2021) MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans. Sci. Adv. doi: 10.1126/sciadv.abj8156
- Park, H.E.H.#, Hwang, W.#, Ham, S.#, Kim., E.#, Altintas, O., Park, S., Son, H.G., Lee, Y., Lee, D., Heo, W.D., and Lee, S.J.V.* (2021) A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling. Nature Comm. doi: 10.1038/s41467-021-25920-w