사람들
Stem Cell and Regenerative
Biology Graduate Program
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Prof Info.
윤기준Ki-Jun Yoon
생명과학기술대학 생명과학과
줄기세포 및 분화연구 발생 및 질환 모델 조직공학 및 오가노이드
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신경줄기세포 연구실에서는 인간의 뇌를 구성하는 다양한 세포들이 정교한 유전자 발현 프로그램을 통해 어떻게 생성되고 조절되는지를 줄기세포와 뇌 오가노이드 모델을 이용해 연구합니다.
또한 줄기세포 유래 모델들을 이용하여 신경발달질환과 퇴행성 뇌질환의 발병 원인을 규명하고 치료법 개발을 도모하고 있습니다.
In the Laboratory of Neural Stem Cell Biology, we study how various cells that make up the human brain are generated and regulated through intricate gene expression programs using stem cells and brain organoid models.
Additionally, we aim to elucidate the causes of neurodevelopmental and neurodegenerative brain diseases and develop treatments by utilizing stem cell-derived models.
또한 줄기세포 유래 모델들을 이용하여 신경발달질환과 퇴행성 뇌질환의 발병 원인을 규명하고 치료법 개발을 도모하고 있습니다.
In the Laboratory of Neural Stem Cell Biology, we study how various cells that make up the human brain are generated and regulated through intricate gene expression programs using stem cells and brain organoid models.
Additionally, we aim to elucidate the causes of neurodevelopmental and neurodegenerative brain diseases and develop treatments by utilizing stem cell-derived models.
- 2018.10 - 현재 Assistant professor, Department of Biological Sciences, KAIST, Korea
- 2017.8 - 2018.9 Research Associate, Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania (Mentor: Dr. Hongjun Song and Dr. Guo-li Ming)
- 2010.1 - 2017.7 Postdoctoral Fellow, Institute of Cell Engineering, Department of Neurology, Johns Hopkins University (Mentor: Dr.Hongjun Song and Dr. Guo-li Ming)
- 2008.9. - 2009. 12 Postdoctoral Fellow, Seoul National University, Korea (Mentor: Dr. Young-Yun Kong)
- 2003.3 - 2008.8 Pohang University of Science and Technology (POSTECH), Korea, Ph. D. (Mentor: Dr. Young-Yun Kong)
- 1999.3 - 2003.2 Pohang University of Science and Technology (POSTECH), Korea, B. S. in Biology
- Neural stem cell
- neuroepitranscriptomics
- brain organoid
- modeling neurodevelopmental and neurodegenerative disorders
- cell replacement therapy
- Kim, M.Y., Kim, M.J., Lee, C., Lee, J., Kim, S.S., Hong, S., Kim, H.T., Seo, J., Yoon, K.J. *, Han, S*. Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer's disease. Exp Mol Med 55 (10), 2177-2189 (2023) (*co-corresponding authors)
- Kim, N.S., Ringeling, F.R., Zhou, Y., Nguyen, H.N., Temme, S.J., Lin, Y.T., Eacker, S., Dawson, V.L., Dawson, T.M., Xiao, B., Hsu, K.S., Canzar, S, Li, W, Worley, P, Christian, K. M., Yoon, K.J.*, Song, H., Ming, G.L*. CYFIP1 dosages exhibit divergent behavioral impact via diametric regulation of NMDAR complex translation in mouse models of psychiatric disorders. Biological Psychiatry (2021) (*co-corresponding authors)
- Yoon, K.J.*, Ringeling, F.R.*, Vissers, C.*, Jacob, F., Pokrass, M., Jimenez-Cyrus, D., Su, Y., Kim, N.S., Zhu, Y., Zheng, L., Kim, S., Wang, X., Hyde, T.M., Weinberger, D.R., Jin, P., Zhuang, X., Regot, S., Regot, S., Canzar, S., He, C., Ming, G.L., Song, H. Temporal Control of Mammalian Cortical Neurogenesis by m6A mRNA Methylation. Cell 171, 1–13 (2017) (*equal contribution)
- Yoon, K.J., Song, G., Qian, X., Pan, J., Rho, H.S., Kim, N.S., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E.M., Huang, W.K., Ringeling, F.R., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C.F., Wu, Q., Christian, K.M., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., Ming, G.L. Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins. Cell Stem Cell 21(3), 349-358 (2017)
- Yoon, K.J., Nguyen, H.N., Ursini, G, Zhang, F, Kim, N.S., Wen, Z., Makri, G., Nauen, D., Shin, J.H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J.E., Hyde, T.M., Christian, K.M., Rapoport, J.L., Weinberger, D.R., Song, H., Ming, G.L. Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell Stem Cell 15(1), 79-91 (2014)