사람들
Stem Cell and Regenerative
Biology Graduate Program
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Prof Info.
김진우Jin Woo Kim
생명과학기술대학
줄기세포 및 분화연구 발생 및 질환 모델
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We are interested in the mechanisms of mammalian retinal development and regeneration.
Main research topics in the laboratory is
1) Complex signaling network for border formation in optic neuroepithelial continuum
2) Intracellular signaling pathways that coordinate proliferation and differentiation of retinal progenitor cells
3) Regulation of neural development and regeneration by intercellular transfer of homeodomain proteins
4) Selected neuronal regeneration in disease tissues
Main research topics in the laboratory is
1) Complex signaling network for border formation in optic neuroepithelial continuum
2) Intracellular signaling pathways that coordinate proliferation and differentiation of retinal progenitor cells
3) Regulation of neural development and regeneration by intercellular transfer of homeodomain proteins
4) Selected neuronal regeneration in disease tissues
- 2006 - 현재 Assistant, Associate, and Full Professor, Department of Biological Sciences, KAIST
- 2002 - 2006 Research Associate, Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
- 1999 - 2002 Post-doc, Cell Death Research Center, Korea University
- BS (1993), MS (1995), Ph.D.(1999), Department of Biological Sciences, KAIST
- Development and regeneration of mammalian retina; Mechanisms and physiological relevance of intercellular homeodomain protein transfer
- Park JW et al. (2023) Orthodenticle homeobox 2 is transported to lysosomes by nuclear budding vesicles. Nature Commun 14: 1111.
- Lim S et al. (2021) mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia. eLife 10: e70079.
- Lee EJ et al. (2019) Global analysis of intercellular homeodomain protein transfer. Cell Rep 28: 712 – 722.
- Choi JH et al. (2018) mTORC1 accelerates retinal development via the immunoproteasome. Nature Commun 9: 2502.
- Moon KH et al. (2018) Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development. Dev Cell 44: 13 – 28.
- Ha T et al. (2017) The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. Cell Rep 19: 351–363.
- Kim Y et al. (2017) The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity. eLife 6: e21303.
- Kim HT et al. (2015) Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons. Cell Rep 13: 990 – 1002.
- Kim N et al. (2014) Regulation of retinal axon growth by secreted Vax1 homeodomain protein. eLife 3: e02671.
- Jo HS et al. (2012) Pten coordinates retinal neurogenesis by regulating Notch signalling. EMBO J. 31: 817 - 828.
- Kim JW et al. (2008) Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium. Genes Dev 22: 3147 - 3157.