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Stem Cell and Regenerative
Biology Graduate Program
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Prof Info.
김세윤Seyun Kim
생명과학기술대학 생명과학과
줄기세포 및 분화연구
우리 연구의 주요 목표는 대사 기반 신호 조절의 생물학적 기능과 분자 메커니즘을 더 잘 이해하는 것입니다.
현재, 우리는 대사 신호 연구의 모든 수준에서 생화학적, 세포 생물학적, 쥐 모델을 사용하여 영양소나 호르몬이 대사 조직 및 기관의 생리적 기능을 어떻게 조절하는지 식별하고 있습니다.
우리의 주요 관심 분야는 이노시톨 폴리포스페이트 생합성 경로와 포유류의 주요 생리적 과정을 조절하는 데 있어 신호적 역할을 포함합니다.
이러한 분자 및 생물학적 정보를 바탕으로 당뇨병, 염증 및 암과 같은 질환의 치료법 개발이 가능할 것으로 강력히 믿습니다.
The main goal of our research is to better understand the biological functions and their molecular mechanisms of metabolism-based signaling regulations.
Currently, we employ all levels of biochemical, cell biological, and mouse models of metabolism signaling research to identify the ways in which nutrients or hormones regulates the physiological functions of metabolic tissues and organs.
Our major interests include inositol polyphosphate biosynthetic pathway and its signaling roles in the control of major physiologic processes in mammals.
We strongly believe obtained molecular and biological information can guide us to the development of improved treatments of medical conditions such as diabetes, inflammation as well as cancer.
현재, 우리는 대사 신호 연구의 모든 수준에서 생화학적, 세포 생물학적, 쥐 모델을 사용하여 영양소나 호르몬이 대사 조직 및 기관의 생리적 기능을 어떻게 조절하는지 식별하고 있습니다.
우리의 주요 관심 분야는 이노시톨 폴리포스페이트 생합성 경로와 포유류의 주요 생리적 과정을 조절하는 데 있어 신호적 역할을 포함합니다.
이러한 분자 및 생물학적 정보를 바탕으로 당뇨병, 염증 및 암과 같은 질환의 치료법 개발이 가능할 것으로 강력히 믿습니다.
The main goal of our research is to better understand the biological functions and their molecular mechanisms of metabolism-based signaling regulations.
Currently, we employ all levels of biochemical, cell biological, and mouse models of metabolism signaling research to identify the ways in which nutrients or hormones regulates the physiological functions of metabolic tissues and organs.
Our major interests include inositol polyphosphate biosynthetic pathway and its signaling roles in the control of major physiologic processes in mammals.
We strongly believe obtained molecular and biological information can guide us to the development of improved treatments of medical conditions such as diabetes, inflammation as well as cancer.
- 2018 - 현재 Associate Professor, Department of Biological Sciences, KAIST
- 2012 - 2017 Assistant Professor, Department of Biological Sciences, KAIST
- 2007-2011 Postdoctoral fellow, Dept. Neuroscience, Johns Hopkins University School of Medicine
- 2007 Ph.D. Dept. Biological Chemistry, Johns Hopkins University School of Medicine
- 2000 M.S. Dept. Molecular Biology, Seoul National University
- 1998 B.S. Dept. Molecular Biology, Seoul National University
- Inositol phosphate metabolism
- Metabolic control of cellular signaling
- Cellular identify and fate control
- Park, S.E.*, Lee, D.*, Jeong, J.W., Lee, S., Park, S.J., Ryu, J., Oh, S.K., Yang, H.+, Fang, S.+, Kim, S.+ (2022) Gut epithelial inositol polyphosphate multikinase alleviates experimental colitis via governing tuft cell homeostasis. Cellular and Molecular Gastroenterology and Hepatology. 14(6):1235. (*equally contributed to this work, +co-corresponding authors)
- Min, H., Kim, W., Hong, S., Lee, S., Jeong, J., Kim, S.+, Seong, R.H.+ (2022) Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca2+influx. Proc. Natl. Acad. Sci. USA. 119(27):e2121520119. (+co-corresponding authors) Beon, J.*, Han, S.*, Park, S.E., Hyun, K., Lee, S., Rhee, H., Seo, J.K., Kim, J., Kim, S.+, Lee, D.+ (2022) IPMK physically binds to the SWI/SNF complex and modulates BRG1 occupancy. eLife 11:e73523. (*equally contributed to this work, +co-corresponding authors)
- Park, S.J.*, Park, H.*, Kim, M.G.*, Zhang, S., Park, S.E., Kim, S.+, Chung, C.+ (2020) Inositol pyrophosphate metabolism regulates presynaptic vesicle cycling at central synapses. iScience. 23(4):101000. (*equally contributed to this work, +co-corresponding authors)
- Park, J., Longo, F., Park, S.J., Lee, S., Bae, M., Tyagi, R., Han, JH., Kim, S.+, Santini, E.+, Klann, E.+, Snyder, S.H.+ (2019) Inositol polyphosphate multikinase mediates extinction of fear memory. Proc. Natl. Acad. Sci. USA. 116(7):2707-2712. (+co-corresponding authors)
- Kim, E., Beon, J., Lee, S., Park, S.J., Ahn, H, Kim, M.G., Park, J.E., Kim, W., Yuk, J.M., Kang, S.J., Lee, S.H., Jo, E.K., Seong, R.H.+, Kim, S.+ (2017) Inositol polyphosphate multikinase promotes Toll-like receptor–induced inflammation by stabilizing TRAF6. Science Advances 3(4):e1602296. (+co-corresponding authors)