사람들
Stem Cell and Regenerative
Biology Graduate Program
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Prof Info.
구본경Bon-Kyoung Koo
유전체교정연구단, 기초과학연구원, 줄기세포&재생생물학 대학원
줄기세포 및 분화연구 발생 및 질환 모델 조직공학 및 오가노이드 최신 줄기세포 연구기술
구본경 박사는 유전학적 방법론과 오가노이드 및 생쥐 모델을 활용하여 소장과 위장의 줄기세포를 연구한다.
특히 줄기세포를 조절하는 다양한 신호전달체계에 관심을 가지고, 다양한 유전학적 방법론을 개발하고 적용하는 연구를 통해 새로운 생물학적 현상을 관찰하고 규명하고자 한다.
Dr. Bon-Kyoung Koo actively employs genetic engineering technologies in organoid and animal models to investigate adult stem cells in the intestine and stomach. He is particularly interested in the regulatory mechanisms behind signalling activity in stem cells and niches.
He also enjoys developing genetic techniques to lead to breakthrough biological discoveries.
특히 줄기세포를 조절하는 다양한 신호전달체계에 관심을 가지고, 다양한 유전학적 방법론을 개발하고 적용하는 연구를 통해 새로운 생물학적 현상을 관찰하고 규명하고자 한다.
Dr. Bon-Kyoung Koo actively employs genetic engineering technologies in organoid and animal models to investigate adult stem cells in the intestine and stomach. He is particularly interested in the regulatory mechanisms behind signalling activity in stem cells and niches.
He also enjoys developing genetic techniques to lead to breakthrough biological discoveries.
- 2006 - 2009 포항공대, 서울대 공영윤 교수 연구실 박사후 연구원
- 2009 - 2013 네덜란드 후브레흐트연구소 박사후 연구원
- 2013 - 2017 영국 케임브리지대 줄기세포연구소 그룹리더
- 2017 - 2023 오스트리아 임바연구소 그룹리더
- 2021 - 2023 기초과학연구원 유전체교정연구단 부연구단장
- 2023 - 현재 기초과학연구원 유전체교정연구단 연구단장
- 1996 - 2000 포항공대 생명과학과 (학사)
- 2000 - 2002 포항공대 생명과학과 (석사)
- 2002 - 2006 포항공대 생명과학과 (박사)
- 생쥐유전학
- 오가노이드
- 성체줄기세포
- 신호전달
- 암발생학
- Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice. Wu SS, Kim S, Lee H, Lee JH, Park SY, Bakonyi R, Teriyapirom I, Hallay N, Pilat-Carotta S, Theussl HC, Kim J, Lee JH, Simons BD, Kim JK, Colozza G, Koo BK. Nat Commun. 2024 Jun 11;15(1):4963. doi: 10.1038/s41467-024-49382-y.
- Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Colozza G, Lee H, Merenda A, Wu SS, Català-Bordes A, Radaszkiewicz TW, Jordens I, Lee JH, Bamford AD, Farnhammer F, Low TY, Maurice MM, Bryja V, Kim J, Koo BK. Sci Adv. 2023 Nov 24;9(47):eadh9673. doi: 10.1126/sciadv.adh9673. Epub 2023 Nov 24.
- Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction. Kim J, Kim S, Lee SY, Jo BK, Oh JY, Kwon EJ, Kim KT, Adpaikar AA, Kim EJ, Jung HS, Kim HR, Roe JS, Hong CP, Kim JK, Koo BK, Cha HJ. Sci Adv. 2023 Nov 24;9(47):eadi8454. doi: 10.1126/sciadv.adi8454. Epub 2023 Nov 24.
- SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection. Wu SS, Lee H, Szép-Bakonyi R, Colozza G, Boese A, Gert KR, Hallay N, Lee JH, Kim J, Zhu Y, Linssen MM, Pilat-Carotta S, Hohenstein P, Theussl HC, Pauli A, Koo BK. Exp Mol Med. 2022 Dec;54(12):2188-2199. doi: 10.1038/s12276-022-00891-0. Epub 2022 Dec 9.
- p57Kip2 imposes the reserve stem cell state of gastric chief cells. Lee JH, Kim S, Han S, Min J, Caldwell B, Bamford AD, Rocha ASB, Park J, Lee S, Wu SS, Lee H, Fink J, Pilat-Carotta S, Kim J, Josserand M, Szep-Bakonyi R, An Y, Ju YS, Philpott A, Simons BD, Stange DE, Choi E, Koo BK, Kim JK. Cell Stem Cell. 2022 May 5;29(5):826-839.e9. doi: 10.1016/j.stem.2022.04.001.
- Tracing oncogene-driven remodelling of the intestinal stem cell niche. Yum MK, Han S, Fink J, Wu SS, Dabrowska C, Trendafilova T, Mustata R, Chatzeli L, Azzarelli R, Pshenichnaya I, Lee E, England F, Kim JK, Stange DE, Philpott A, Lee JH, Koo BK, Simons BD. Nature. 2021 Jun;594(7863):442-447. doi: 10.1038/s41586-021-03605-0. Epub 2021 Jun 2.
- A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis. Tsukiyama T, Zou J, Kim J, Ogamino S, Shino Y, Masuda T, Merenda A, Matsumoto M, Fujioka Y, Hirose T, Terai S, Takahashi H, Ishitani T, Nakayama KI, Ohba Y, Koo BK, Hatakeyama S. Nat Commun. 2020 Sep 15;11(1):4586. doi: 10.1038/s41467-020-18257-3.
- Human organoids: model systems for human biology and medicine. Kim J, Koo BK, Knoblich JA. Nat Rev Mol Cell Biol. 2020 Oct;21(10):571-584. doi: 10.1038/s41580-020-0259-3. Epub 2020 Jul 7.
- Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations. Seidlitz T, Chen YT, Uhlemann H, Schölch S, Kochall S, Merker SR, Klimova A, Hennig A, Schweitzer C, Pape K, Baretton GB, Welsch T, Aust DE, Weitz J, Koo BK, Stange DE. Gastroenterology. 2019 Dec;157(6):1599-1614.e2. doi: 10.1053/j.gastro.2019.09.026. Epub 2019 Oct 1.
- Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK. Cell Stem Cell. 2019 Sep 5;25(3):342-356.e7. doi: 10.1016/j.stem.2019.07.008. Epub 2019 Aug 15.