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Minee-Liane Choi최민이
Department of Brain and Cognitive Sciences
Tissue Engineering and Organoids
We study diseases of the nervous system, focusing on Parkinson’s diseaes and Dementia.
These diseases are challenging to treat due to the difficulty of accessing the diseased brain and their individual heterogeneity.
To overcome the inherent limitations of studying brain disorders, we use human stem cells generated from real patients (hiPSC).
This approach allows us to profile the diseased state of a patient's individual brain cells and identifying mechanistic subtypes using a 'disease-in-a-dish' paradigm.
By utilizing patient-derived iPSCs, our overarching goal is to develop a preclinical testbed for brain disorders. We also employ AI to predict the most suitable drug combinations for individual patients’ pathological and cellular subtypes, thereby overcoming the limitations of biological experiments in accurately capturing the heterogeneity of diseases.
These diseases are challenging to treat due to the difficulty of accessing the diseased brain and their individual heterogeneity.
To overcome the inherent limitations of studying brain disorders, we use human stem cells generated from real patients (hiPSC).
This approach allows us to profile the diseased state of a patient's individual brain cells and identifying mechanistic subtypes using a 'disease-in-a-dish' paradigm.
By utilizing patient-derived iPSCs, our overarching goal is to develop a preclinical testbed for brain disorders. We also employ AI to predict the most suitable drug combinations for individual patients’ pathological and cellular subtypes, thereby overcoming the limitations of biological experiments in accurately capturing the heterogeneity of diseases.
2023 – Present
Assistant Professor, Department of Brain and Cognitive Sciences, KAIST2017 – 2022
Research Fellow (laboratory secondment), The Francis Crick Institute, UK2014 – 2022
Postdoctoral Research Fellow, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, UK2012 – 2013
Researcher, Wolfson Institute for Biomedical Research, UCL, UK
- Ph.D. in Clinical Neurosciences, University of Cambridge (2013)
- Development of a patient-derived stem cell-based brain organoid platform for preclinical testing of therapeutics for neurological disorders
- Investigation of key pathogenic mechanisms in neurodegenerative diseases, including neuronal cell death, protein aggregation, and mitochondrial dysfunction
- D'Sa K, Evans JR, Virdi GS, Vecchi G, Adam A, Bertolli O, Fleming J, Chang H, Leighton C, Horrocks M, Athauda D+, Choi ML+, Gandhi S+ "Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models" Nature Machine Intelligence, 11 Aug (2023) (+Equally contributed)
- Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, FedotovaE, Berezhnov AV, De S, Peddie C, Athauda D, Virdi GS, Zhang W, Evans JR, Angelova PR, Esteras N, Morris K, Tosatto L, Little D, Gissen P, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S “Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity” Nature Neuroscience 25, 1134–1148 (2022).
- Angelova PR*, Choi ML*, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, Pavlov EV, Klenerman D, Abramov AY, Gandhi S “Alphasynuclein aggregation drives ferroptosis in Parkinson’s disease: an interplayof iron, calcium and lipid peroxidation” Cell death & Differentiation. 27, 2781-2796 (2020) (*Equally contributed)
- Hughes CD*, Choi ML*, Ryten M, Hopkins L, Drews A, Botía JA, Iljina M, Rodrigues M, Gagliano SA, Gandhi S, Bryant C, Klenerman D “Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play aninitiating role in Parkinson's disease pathogenesis” Acta Neuropathologica137(1), 103-120 (2019). (+Equally contributed)