Tissue Engineering and Organoids

Human tissues are composed of various cell types organized into complex structures. During development, the sequential differentiation of stem cells leads to tissue formation, while in adult tissues, resident stem cells maintain tissue function. Tissue engineering is an advanced technology that integrates cells, biomaterials, and physical or chemical factors to create tissue-like structures for repairing or replacing biological tissues. Stem cells with differentiation potential—including adult stem cells, embryonic stem cells, and induced pluripotent stem cells—can be used to generate organ-like structures known as organoids. At our graduate school, we leverage stem cell-derived organoids and tissue engineering technologies to investigate disease mechanisms, develop personalized drug discovery strategies, and create transplantable tissues and organs.