Cells are continuously subjected to physical stimuli, leading to changes in functions such as shape, movement, and survival. Our mission is to elucidate the physical principles governing these cellular dynamics through quantitative experiments and analyses within controlled environments. At the core of our work is the interdisciplinary realm of mechanobiology, where we aim to uncover the connection between mechanical stressors—such as tension, shear, electrical fields, or structural topography—and subsequent cellular responses.
Our research endeavors to:
- Delineate the influence of physical forces on cell physiology within cell mechanics.
- Explore how cells interpret and convert mechanical signals into critical physiological events in cellular mechanobiology.
- Harness AI-based analytics to classify cells, advancing diagnostics and therapeutic strategies.
To support these endeavors, we engineer various experimental platforms designed to assess mechano-responses at the cellular scale. We develop 3D spheroid disease models that more closely replicate in vivo tissue properties than traditional 2D cultures, providing a more faithful representation for our investigations. We gain profound insights into cellular functions through gene and protein assays, complemented by mechanical stress evaluations via traction force and monolayer stress microscopy.
This integrative mechanical framework, paired with high-capacity imaging, sharpens our understanding of cellular distinctions, enhancing our predictive power over disease progression and therapeutic efficacy. Ultimately, our work contributes to advancements in medical science.