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Stem Cell and Regenerative
Biology Graduate Program

Bon-Kyoung Koo

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Prof Info.

Bon-Kyoung Koo.

Center for Genome Engineering, Institute for Basic Science, Graduate School of Stem Cell and Regenerative Biology

줄기세포 및 분화연구 발생 및 질환 모델 조직공학 및 오가노이드 최신 줄기세포 연구기술

Contact.

042-878-8310
koobk@ibs.re.kr
center for genome engineering

Lab Info.

Dr. Bon-Kyoung Koo actively employs genetic engineering technologies in organoid and animal models to investigate adult stem cells in the intestine and stomach. He is particularly interested in the regulatory mechanisms behind signalling activity in stem cells and niches.
He also enjoys developing genetic techniques to lead to breakthrough biological discoveries.

Profile.

  • 2023 – Present
    Director, Center for Genome Engineering, Institute for Basic Science (IBS), Republic of Korea

  • 2021 – 2023
    Deputy Director, Center for Genome Engineering, Institute for Basic Science (IBS), Republic of Korea

  • 2017 – 2023
    Group Leader, Institute of Molecular Biotechnology (IMBA), Austria

  • 2013 – 2017
    Group Leader, Stem Cell Institute, University of Cambridge, United Kingdom

  • 2009 – 2013
    Postdoctoral Researcher, Hubrecht Institute, the Netherlands

  • 2006 – 2009
    Postdoctoral Researcher, Laboratory of Professor Young-Yun Kong, POSTECH and Seoul National University, Republic of Korea

Education.

  • 2002 – 2006
    Ph.D. in Life Sciences, Pohang University of Science and Technology (POSTECH), Republic of Korea

  • 2000 – 2002
    M.S. in Life Sciences, Pohang University of Science and Technology (POSTECH), Republic of Korea

  • 1996 – 2000
    B.S. in Life Sciences, Pohang University of Science and Technology (POSTECH), Republic of Korea

Main Research areas.

  • Mouse Genetics

  • Organoids

  • Adult Stem Cells

  • Signal Transduction

  • Cancer Biology

Main Publications.

  • Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice. Wu SS, Kim S, Lee H, Lee JH, Park SY, Bakonyi R, Teriyapirom I, Hallay N, Pilat-Carotta S, Theussl HC, Kim J, Lee JH, Simons BD, Kim JK, Colozza G, Koo BK. Nat Commun. 2024 Jun 11;15(1):4963. doi: 10.1038/s41467-024-49382-y.
  • Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Colozza G, Lee H, Merenda A, Wu SS, Català-Bordes A, Radaszkiewicz TW, Jordens I, Lee JH, Bamford AD, Farnhammer F, Low TY, Maurice MM, Bryja V, Kim J, Koo BK. Sci Adv. 2023 Nov 24;9(47):eadh9673. doi: 10.1126/sciadv.adh9673. Epub 2023 Nov 24.
  • Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction. Kim J, Kim S, Lee SY, Jo BK, Oh JY, Kwon EJ, Kim KT, Adpaikar AA, Kim EJ, Jung HS, Kim HR, Roe JS, Hong CP, Kim JK, Koo BK, Cha HJ. Sci Adv. 2023 Nov 24;9(47):eadi8454. doi: 10.1126/sciadv.adi8454. Epub 2023 Nov 24.
  • SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection. Wu SS, Lee H, Szép-Bakonyi R, Colozza G, Boese A, Gert KR, Hallay N, Lee JH, Kim J, Zhu Y, Linssen MM, Pilat-Carotta S, Hohenstein P, Theussl HC, Pauli A, Koo BK. Exp Mol Med. 2022 Dec;54(12):2188-2199. doi: 10.1038/s12276-022-00891-0. Epub 2022 Dec 9.
  • p57Kip2 imposes the reserve stem cell state of gastric chief cells. Lee JH, Kim S, Han S, Min J, Caldwell B, Bamford AD, Rocha ASB, Park J, Lee S, Wu SS, Lee H, Fink J, Pilat-Carotta S, Kim J, Josserand M, Szep-Bakonyi R, An Y, Ju YS, Philpott A, Simons BD, Stange DE, Choi E, Koo BK, Kim JK. Cell Stem Cell. 2022 May 5;29(5):826-839.e9. doi: 10.1016/j.stem.2022.04.001.
  • Tracing oncogene-driven remodelling of the intestinal stem cell niche. Yum MK, Han S, Fink J, Wu SS, Dabrowska C, Trendafilova T, Mustata R, Chatzeli L, Azzarelli R, Pshenichnaya I, Lee E, England F, Kim JK, Stange DE, Philpott A, Lee JH, Koo BK, Simons BD. Nature. 2021 Jun;594(7863):442-447. doi: 10.1038/s41586-021-03605-0. Epub 2021 Jun 2.
  • A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis. Tsukiyama T, Zou J, Kim J, Ogamino S, Shino Y, Masuda T, Merenda A, Matsumoto M, Fujioka Y, Hirose T, Terai S, Takahashi H, Ishitani T, Nakayama KI, Ohba Y, Koo BK, Hatakeyama S. Nat Commun. 2020 Sep 15;11(1):4586. doi: 10.1038/s41467-020-18257-3.
  • Human organoids: model systems for human biology and medicine. Kim J, Koo BK, Knoblich JA. Nat Rev Mol Cell Biol. 2020 Oct;21(10):571-584. doi: 10.1038/s41580-020-0259-3. Epub 2020 Jul 7.
  • Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations. Seidlitz T, Chen YT, Uhlemann H, Schölch S, Kochall S, Merker SR, Klimova A, Hennig A, Schweitzer C, Pape K, Baretton GB, Welsch T, Aust DE, Weitz J, Koo BK, Stange DE. Gastroenterology. 2019 Dec;157(6):1599-1614.e2. doi: 10.1053/j.gastro.2019.09.026. Epub 2019 Oct 1.
  • Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK. Cell Stem Cell. 2019 Sep 5;25(3):342-356.e7. doi: 10.1016/j.stem.2019.07.008. Epub 2019 Aug 15.