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Ki-Jun Yoon윤기준
Department of Biological Sciences
Stem Cell and Differentiation Research Developmental and disease models Tissue Engineering and Organoids
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In the Laboratory of Neural Stem Cell Biology, we study how various cells that make up the human brain are generated and regulated through intricate gene expression programs using stem cells and brain organoid models.
Additionally, we aim to elucidate the causes of neurodevelopmental and neurodegenerative brain diseases and develop treatments by utilizing stem cell-derived models.
Additionally, we aim to elucidate the causes of neurodevelopmental and neurodegenerative brain diseases and develop treatments by utilizing stem cell-derived models.
- 2018.10 - Present Assistant professor, Department of Biological Sciences, KAIST, Korea
- 2017.8 - 2018.9 Research Associate, Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania (Mentor: Dr. Hongjun Song and Dr. Guo-li Ming)
- 2010.1 - 2017.7 Postdoctoral Fellow, Institute of Cell Engineering, Department of Neurology, Johns Hopkins University (Mentor: Dr.Hongjun Song and Dr. Guo-li Ming)
- 2008.9. - 2009. 12 Postdoctoral Fellow, Seoul National University, Korea (Mentor: Dr. Young-Yun Kong)
- 2003.3 - 2008.8 Pohang University of Science and Technology (POSTECH), Korea, Ph. D. (Mentor: Dr. Young-Yun Kong)
- 1999.3 - 2003.2 Pohang University of Science and Technology (POSTECH), Korea, B. S. in Biology
- Neural stem cell
- neuroepitranscriptomics
- brain organoid
- modeling neurodevelopmental and neurodegenerative disorders
- cell replacement therapy
- Kim, M.Y., Kim, M.J., Lee, C., Lee, J., Kim, S.S., Hong, S., Kim, H.T., Seo, J., Yoon, K.J. *, Han, S*. Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer's disease. Exp Mol Med 55 (10), 2177-2189 (2023) (*co-corresponding authors)
- Kim, N.S., Ringeling, F.R., Zhou, Y., Nguyen, H.N., Temme, S.J., Lin, Y.T., Eacker, S., Dawson, V.L., Dawson, T.M., Xiao, B., Hsu, K.S., Canzar, S, Li, W, Worley, P, Christian, K. M., Yoon, K.J.*, Song, H., Ming, G.L*. CYFIP1 dosages exhibit divergent behavioral impact via diametric regulation of NMDAR complex translation in mouse models of psychiatric disorders. Biological Psychiatry (2021) (*co-corresponding authors)
- Yoon, K.J.*, Ringeling, F.R.*, Vissers, C.*, Jacob, F., Pokrass, M., Jimenez-Cyrus, D., Su, Y., Kim, N.S., Zhu, Y., Zheng, L., Kim, S., Wang, X., Hyde, T.M., Weinberger, D.R., Jin, P., Zhuang, X., Regot, S., Regot, S., Canzar, S., He, C., Ming, G.L., Song, H. Temporal Control of Mammalian Cortical Neurogenesis by m6A mRNA Methylation. Cell 171, 1–13 (2017) (*equal contribution)
- Yoon, K.J., Song, G., Qian, X., Pan, J., Rho, H.S., Kim, N.S., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E.M., Huang, W.K., Ringeling, F.R., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C.F., Wu, Q., Christian, K.M., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., Ming, G.L. Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins. Cell Stem Cell 21(3), 349-358 (2017)
- Yoon, K.J., Nguyen, H.N., Ursini, G, Zhang, F, Kim, N.S., Wen, Z., Makri, G., Nauen, D., Shin, J.H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J.E., Hyde, T.M., Christian, K.M., Rapoport, J.L., Weinberger, D.R., Song, H., Ming, G.L. Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell Stem Cell 15(1), 79-91 (2014)