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Seung-Jae V. Lee이승재
Department of Biological Sciences
Developmental and disease models
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The Center for RNA-Mediated Healthy Longevity studies how changes in RNA during the aging process affect aging and longevity.
Specifically, we investigate the roles of mRNA quality control, and noncoding RNAs including circular RNA, long noncoding RNA and tRNA-derived small RNA, in aging.
Our research team primarily utilizes Caenorhabditis elegans, an optimal model for aging research, and also tests whether our findings are evolutionarily conserved in cultured mammalian cells and mice.
Specifically, we investigate the roles of mRNA quality control, and noncoding RNAs including circular RNA, long noncoding RNA and tRNA-derived small RNA, in aging.
Our research team primarily utilizes Caenorhabditis elegans, an optimal model for aging research, and also tests whether our findings are evolutionarily conserved in cultured mammalian cells and mice.
- 2019.2 - Present Professor, KAIST, South Korea
- 2016.3 - 2019.2 Tenured Associate Professor, POSTECH, South Korea
- 2013.3 - 2016.2 Associate Professor, POSTECH, South Korea
- 2009.1 - 2013.2 Assistant Professor, POSTECH, South Korea
- 2004.4 - 2008.12 Postdoctoral Fellow, University of California, San Francisco, CA, USA
- 2003.4 - 2004.3 Postdoctoral Fellow, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Ph. D. 2003 Department of Biological chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- M. S. 1997 Department of Microbiology, Seoul National University, Seoul, South Korea
- B. S. 1995 Department of Microbiology, Seoul National University, Seoul, South Korea
- Regulation of aging and longevity
- Molecular genetics using Caenorhabditis elegans
- The role of mRNA surveillance and ribosome-associated quality control in aging
- Functional analysis of noncoding RNAs in aging processes
- Sohn, J.#, Kwon, S.#, Lee, G.Y.#, Kim, S.S., Lee, Y., Lee, J., Jung, Y., Ham, S., Park, H.E.H., Park, S., Ha, S.G., Lee, D., and Lee, S.J.V.* (2024) HLH-30/TFEB-regulated autophagy mediates sexual dimorphism in immunity in Caenorhabditis elegans. Autophagy doi: 10.1080/15548627.2024.2375779
- Kim, E.#, Annibal, A.#, Lee, Y.#, Park, H.E.H.#, Ham, S.#, Jeong, D.E., Kim, Y., Park, S., Kwon, S., Jung, Y., Park, J., Kim, S.S., Antebi, A.*, and Lee, S.J.V.* (2023) Inhibition of mitochondrial aconitase enhances immunity by modulating oxaloacetate and the mitochondrial UPR. Nature Comm. doi: 10.1038/s41467-023-39393-6
- Ham, S.#, Kim, S.S.#, Park, S., Kim, E.J.E., Kwon, S., Park, H.E.H., Jung, Y., and Lee, S.J.V.* (2022) Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans. Genome Res. 32(11-12):2003-2014
- Jung, Y.#, Artan, M.#, Kim, N.#, Yeom, J.#, Hwang, A.B., Jeong, D.E., Altintas, O., Seo, K., Seo, M., Lee, D., Hwang, W., Lee, Y., Sohn, J., Kim, E.J.E., Ju, S., Han, S.K., Nam, H.J., Adams, L., Ryu, Y., Moon, D.J., Kang, C., Yoo, J.Y., Park, S.K., Ha, C.M., Hansen, M., Kim, S., Lee, C.*, Park, S.Y.*, and Lee, S.J.V.* (2021) MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans. Sci. Adv. doi: 10.1126/sciadv.abj8156
- Park, H.E.H.#, Hwang, W.#, Ham, S.#, Kim., E.#, Altintas, O., Park, S., Son, H.G., Lee, Y., Lee, D., Heo, W.D., and Lee, S.J.V.* (2021) A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling. Nature Comm. doi: 10.1038/s41467-021-25920-w