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Prof Info.
Seyun Kim.
Department of Biological Sciences
줄기세포 및 분화연구
The main goal of our research is to better understand the biological functions and their molecular mechanisms of metabolism-based signaling regulations.
Currently, we employ all levels of biochemical, cell biological, and mouse models of metabolism signaling research to identify the ways in which nutrients or hormones regulates the physiological functions of metabolic tissues and organs.
Our major interests include inositol polyphosphate biosynthetic pathway and its signaling roles in the control of major physiologic processes in mammals.
We strongly believe obtained molecular and biological information can guide us to the development of improved treatments of medical conditions such as diabetes, inflammation as well as cancer.
Currently, we employ all levels of biochemical, cell biological, and mouse models of metabolism signaling research to identify the ways in which nutrients or hormones regulates the physiological functions of metabolic tissues and organs.
Our major interests include inositol polyphosphate biosynthetic pathway and its signaling roles in the control of major physiologic processes in mammals.
We strongly believe obtained molecular and biological information can guide us to the development of improved treatments of medical conditions such as diabetes, inflammation as well as cancer.
- 2018 - Present : Associate Professor, Department of Biological Sciences, KAIST
- 2012 - 2017 : Assistant Professor, Department of Biological Sciences, KAIST
- 2007-2011 Postdoctoral fellow, Dept. Neuroscience, Johns Hopkins University School of Medicine
- 2007 Ph.D. Dept. Biological Chemistry, Johns Hopkins University School of Medicine
- 2000 M.S. Dept. Molecular Biology, Seoul National University
- 1998 B.S. Dept. Molecular Biology, Seoul National University
- Inositol phosphate metabolism
- Metabolic control of cellular signaling
- Cellular identify and fate control
- Park, S.E.*, Lee, D.*, Jeong, J.W., Lee, S., Park, S.J., Ryu, J., Oh, S.K., Yang, H.+, Fang, S.+, Kim, S.+ (2022) Gut epithelial inositol polyphosphate multikinase alleviates experimental colitis via governing tuft cell homeostasis. Cellular and Molecular Gastroenterology and Hepatology. 14(6):1235. (*equally contributed to this work, +co-corresponding authors)
- Min, H., Kim, W., Hong, S., Lee, S., Jeong, J., Kim, S.+, Seong, R.H.+ (2022) Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca2+influx. Proc. Natl. Acad. Sci. USA. 119(27):e2121520119. (+co-corresponding authors) Beon, J.*, Han, S.*, Park, S.E., Hyun, K., Lee, S., Rhee, H., Seo, J.K., Kim, J., Kim, S.+, Lee, D.+ (2022) IPMK physically binds to the SWI/SNF complex and modulates BRG1 occupancy. eLife 11:e73523. (*equally contributed to this work, +co-corresponding authors)
- Park, S.J.*, Park, H.*, Kim, M.G.*, Zhang, S., Park, S.E., Kim, S.+, Chung, C.+ (2020) Inositol pyrophosphate metabolism regulates presynaptic vesicle cycling at central synapses. iScience. 23(4):101000. (*equally contributed to this work, +co-corresponding authors)
- Park, J., Longo, F., Park, S.J., Lee, S., Bae, M., Tyagi, R., Han, JH., Kim, S.+, Santini, E.+, Klann, E.+, Snyder, S.H.+ (2019) Inositol polyphosphate multikinase mediates extinction of fear memory. Proc. Natl. Acad. Sci. USA. 116(7):2707-2712. (+co-corresponding authors)
- Kim, E., Beon, J., Lee, S., Park, S.J., Ahn, H, Kim, M.G., Park, J.E., Kim, W., Yuk, J.M., Kang, S.J., Lee, S.H., Jo, E.K., Seong, R.H.+, Kim, S.+ (2017) Inositol polyphosphate multikinase promotes Toll-like receptor–induced inflammation by stabilizing TRAF6. Science Advances 3(4):e1602296. (+co-corresponding authors)